03 October 2017

Symptoms and Signs of Mesothelioma Which You Should Know as Early as Possible

Symptoms and Signs of Mesothelioma Which You Should Know as Early as Possible
Symptoms and Signs of Mesothelioma Which You Should Know as Early as Possible - Malignancies involving the mesothelial cells of the human body, including the pleura, the peritoneum, the pericardium, and the testes, are known as malignant mesothelioma, either local or diffuse. Most, but not all, cases of malignant mesothelioma in pleural (lung cancer) are usually associated with exposure to asbestos. Patients with malignant pleural mesothelioma, 77% have been exposed to asbestos in their past. The diagnosis of mesothelioma is difficult to enforce because the results of effusion fluid analysis from cancer are usually undiagnostic. Mesothelioma is more common in males than females and it occurs most commonly in the fifth decade until the 7th decade. Most cases (about 90%) of malignant mesothelioma occur in the pleura.

From the histology there are 3 types of mesothelioma, mesothelioma sarcomatous, mesothelioma epithelial, and mesothelioma mixed (mixed). Pleural mesothelioma usually begins as plaque and nodules that combine to produce sheetlike neoplasm. Tumor growth usually begins at the bottom of the chest. Tumors can attack the diaphragm and envelop the surface of the lung and the interlobar gap.

As the disease progresses, it often extends to the lung parenchyma, chest wall and mediastinal wall. Pleural mesothelioma can spread to the esophagus, ribs, spine, brachial plexus, and superior cava vein.

Asbestos, amphibole asbestos, asbestos-crocidolite, and amosite asbestos in particular, are the major carcinogens involved in pathogenesis. Exposure to chrysotile asbestos is associated with a lower incidence of mesothelioma. Industrial areas often associated with mesothelioma due to asbestos exposure include the mining industry, shipbuilding involving the use of asbestos, the manufacture of cement asbestos, ceramics, grinding paper, auto parts, and railway repair plants.

Clinical manifestations / clinical symptoms of mesothelioma that occur are:

    Dyspnea and nonpleuritic chest wall pain are the most common symptoms of malignant mesothelioma. (Approximately 60-90% of patients experience symptoms of chest pain or dyspnea.)

    In patients with malignant mesothelioma, physical findings of pleural effusion are usually known by percussion and auscultation.

    In rare cases, malignant mesothelioma manifests as cord compression, brachial plexopathy, Horner syndrome, or superior vena cava syndrome. Death is usually caused by infection or respiratory failure from the development of mesothelioma.

    The main areas that often occur in the pleura (87%), peritoneum (5.1%), and pericardium (0.4%).

Signs of mesothelioma 

Mesothelioma sufferers may include, such as shortness of breath due to fluid around the lungs, swollen abdomen, chest pain in the walls, coughing, fatigue, and weight loss. These symptoms usually come slowly.

More than 80% of mesothelioma cases are caused by exposure to asbestos dust or debris. The greater the exposure the greater the risk. By 2013 about 125 million people have been exposed to asbestos at work. High rates of disease occur in people who mine asbestos, produce products from asbestos, work with asbestos products, live with asbestos workers, or work in buildings containing asbestos. Washing clothes from someone who works closely with asbestos also increases the risk of contracting the disease. Other risk factors include genetic and infection with simian virus 40. Diagnosis can be seen based on X-ray results and CT scan findings.

Prevention can be done is to reduce exposure to asbestos while working with a dust-proof mask. For self treatment is often done by surgery, radiation therapy, and chemotherapy. A procedure known as pleurodesis, which involves using substances such as talcum powder for pleural scars together, can be used to prevent more fluid accumulating around the lungs. While chemotherapy is often given cisplatin and pemetrexed drugs. The percentage of people who can survive for five years after being diagnosed with this cancer, on average only 8% in the United States.

By 2013 about 50,000 people have been affected by mesothelioma and about 34,000 people die from the disease. Mesothelioma levels vary in different regions of the world. Levels are higher in Australia, UK, and lower in Japan. This happens to about 3,000 people per year in the United States. This happens more often in men than in women. The level of disease has increased since the 1950s. Diagnosis usually occurs after age 65 and most deaths occur in people aged about 70 years. This disease is rarely encountered before commercial use of asbestos.

That's what I can tell you. For more details you can ask directly / contact an internal organ specialist and read his article at mesothelioma.net or treatmesothelioma.org.
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